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- Bba560000fdc3bb6b2e321f7ae5d74922 NCIT_P378 "NCI" @default.
- Bba560000fdc3bb6b2e321f7ae5d74922 type Axiom @default.
- Bba560000fdc3bb6b2e321f7ae5d74922 annotatedProperty IAO_0000115 @default.
- Bba560000fdc3bb6b2e321f7ae5d74922 annotatedSource NCIT_C133691 @default.
- Bba560000fdc3bb6b2e321f7ae5d74922 annotatedTarget "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, aumolertinib binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.