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- Bba655898f8ce10d0f2e748928e437dc8 NCIT_P378 "BIOCARTA" @default.
- Bba655898f8ce10d0f2e748928e437dc8 type Axiom @default.
- Bba655898f8ce10d0f2e748928e437dc8 annotatedProperty NCIT_P325 @default.
- Bba655898f8ce10d0f2e748928e437dc8 annotatedSource NCIT_C39184 @default.
- Bba655898f8ce10d0f2e748928e437dc8 annotatedTarget "Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed from the A and B chains. PDGF is active to a differing degree depending on which dimer is formed (AA, AB, or BB). The PDGF Receptor (PDGFR) is also a dimer and can form from the combination of the alpha and beta chains in any order (alpha-alpha, alpha-beta, beta-beta). The PDGFR dimer is only formed after ligand binding so the alpha/beta composition of the receptor can be influenced by the form of PDGF that is present. Upon binding of ligand the PDGFR is tyrosine phosphorylated and leads to the phosphorylation of several other cellular proteins. (This definition may be outdated - see the DesignNote.)" @default.