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- Bbad13288e2488ef0e82c5c7a3befdf47 NCIT_P378 "NCI" @default.
- Bbad13288e2488ef0e82c5c7a3befdf47 type Axiom @default.
- Bbad13288e2488ef0e82c5c7a3befdf47 annotatedProperty IAO_0000115 @default.
- Bbad13288e2488ef0e82c5c7a3befdf47 annotatedSource NCIT_C114501 @default.
- Bbad13288e2488ef0e82c5c7a3befdf47 annotatedTarget "A radioconjugate composed of an affinity-matured antibody fragment, the A11 minibody, directed against human prostate stem cell antigen (PSCA), and conjugated with the radioisotope iodine I 124, that can potentially be used as an imaging agent for positron emission tomography (PET)/computed tomography (CT). The minibody moiety of iodine I 124-labeled anti-PSCA A11 minibody selectively targets and binds to PSCA. The PSCA-expressing tumor cells can then be visualized using PET/CT. PSCA, a cell surface antigen expressed in normal human prostate and bladder, is overexpressed in a variety of cancers, including bladder, pancreatic, and prostate cancer. The A11 minibody is formed by the fusion of a single chain Fv fragment with the immunoglobulin G1 CH3 domain." @default.