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- Bbb0c1da56543adb56a1efcd94b7e1601 NCIT_P378 "NCI" @default.
- Bbb0c1da56543adb56a1efcd94b7e1601 type Axiom @default.
- Bbb0c1da56543adb56a1efcd94b7e1601 annotatedProperty IAO_0000115 @default.
- Bbb0c1da56543adb56a1efcd94b7e1601 annotatedSource NCIT_C153122 @default.
- Bbb0c1da56543adb56a1efcd94b7e1601 annotatedTarget "An orally available and selective inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, INCB081776 targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with enhanced immunosuppression, drug resistance and poor prognosis." @default.