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- Bbb7383d046309d7f9d61a00d0e576413 NCIT_P378 "NCI" @default.
- Bbb7383d046309d7f9d61a00d0e576413 type Axiom @default.
- Bbb7383d046309d7f9d61a00d0e576413 annotatedProperty IAO_0000115 @default.
- Bbb7383d046309d7f9d61a00d0e576413 annotatedSource NCIT_C28911 @default.
- Bbb7383d046309d7f9d61a00d0e576413 annotatedTarget "A beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefaclor binds to and inactivates penicillin-binding proteins (PBP) located in bacterial cytoplasmic membranes. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.