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- Bbca19f3f3ea0d9e4130bf3f6c3bfe4be NCIT_P378 "NCI" @default.
- Bbca19f3f3ea0d9e4130bf3f6c3bfe4be type Axiom @default.
- Bbca19f3f3ea0d9e4130bf3f6c3bfe4be annotatedProperty IAO_0000115 @default.
- Bbca19f3f3ea0d9e4130bf3f6c3bfe4be annotatedSource NCIT_C101519 @default.
- Bbca19f3f3ea0d9e4130bf3f6c3bfe4be annotatedTarget "A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. Edicotinib blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation, recruitment, and activation as well as the regulation of cell proliferation." @default.