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- Bbd09d6236c5e64831d9ee8d8e26be9c4 NCIT_P378 "NCI" @default.
- Bbd09d6236c5e64831d9ee8d8e26be9c4 type Axiom @default.
- Bbd09d6236c5e64831d9ee8d8e26be9c4 annotatedProperty IAO_0000115 @default.
- Bbd09d6236c5e64831d9ee8d8e26be9c4 annotatedSource NCIT_C159764 @default.
- Bbd09d6236c5e64831d9ee8d8e26be9c4 annotatedTarget "A fully human immunoglobulin G1 (IgG1) antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, anti-CTLA-4 monoclonal antibody REGN4659 targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.