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- Bbd4990f8b03c734671efa51316e95f6c NCIT_P378 "NCI" @default.
- Bbd4990f8b03c734671efa51316e95f6c type Axiom @default.
- Bbd4990f8b03c734671efa51316e95f6c annotatedProperty IAO_0000115 @default.
- Bbd4990f8b03c734671efa51316e95f6c annotatedSource NCIT_C1687 @default.
- Bbd4990f8b03c734671efa51316e95f6c annotatedTarget "The mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST)." @default.