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- Bbe4c8562f00b4f2fe2c00248f1b65f9b hasDbXref "FBC:GM" @default.
- Bbe4c8562f00b4f2fe2c00248f1b65f9b type Axiom @default.
- Bbe4c8562f00b4f2fe2c00248f1b65f9b annotatedProperty IAO_0000115 @default.
- Bbe4c8562f00b4f2fe2c00248f1b65f9b annotatedSource FBcv_0005066 @default.
- Bbe4c8562f00b4f2fe2c00248f1b65f9b annotatedTarget "Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a conditional repressor permits further refinement of this expression pattern." @default.