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- Bbf0c57c2c6e6191638f85c75da82fa6e NCIT_P378 "NCI" @default.
- Bbf0c57c2c6e6191638f85c75da82fa6e type Axiom @default.
- Bbf0c57c2c6e6191638f85c75da82fa6e annotatedProperty IAO_0000115 @default.
- Bbf0c57c2c6e6191638f85c75da82fa6e annotatedSource NCIT_C2529 @default.
- Bbf0c57c2c6e6191638f85c75da82fa6e annotatedTarget "A vaccine containing a clustered pancarcinoma carbohydrate antigen, Thomsen-Friedenreich (TF) antigen, conjugated with keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. TF antigen is a disaccharide epitope (galactose-beta1-3-N-acetylgalactose), normally O-linked to serine or threonine of tumor-associated epithelial mucins. This vaccine contains the TF epitope cluster (c) that is synthesized by linking 3 copies of the TF epitope on a threonine backbone to achieve the essential immunogenic structure. KLH is a hapten carrier and serves as an immunostimulant to improve immune recognition. Vaccination with TF(c)-KLH peptide vaccine may produce antibodies and elicit a cytotoxic T lymphocyte (CTL) response against those tumor cells expressing TF antigen, resulting in decreased tumor growth." @default.