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- Bbf2a86f94d1da3ef273bc81bb4bc673d NCIT_P378 "NCI" @default.
- Bbf2a86f94d1da3ef273bc81bb4bc673d type Axiom @default.
- Bbf2a86f94d1da3ef273bc81bb4bc673d annotatedProperty IAO_0000115 @default.
- Bbf2a86f94d1da3ef273bc81bb4bc673d annotatedSource NCIT_C129712 @default.
- Bbf2a86f94d1da3ef273bc81bb4bc673d annotatedTarget "A calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis." @default.