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- Bbf72a607ee8426a9834aaaa8caee5730 NCIT_P378 "NCI" @default.
- Bbf72a607ee8426a9834aaaa8caee5730 type Axiom @default.
- Bbf72a607ee8426a9834aaaa8caee5730 annotatedProperty IAO_0000115 @default.
- Bbf72a607ee8426a9834aaaa8caee5730 annotatedSource NCIT_C5420 @default.
- Bbf72a607ee8426a9834aaaa8caee5730 annotatedTarget "A sensory neuropathy caused by the effects of a distant neoplasm (usually a small cell carcinoma). It is usually caused by the production of anti-neuronal autoantibodies: anti-Hu (ANNA-1) or anti-CV2 (CRMP-5), which result in cytotoxic T-cell mediated destruction of dorsal root ganglia. It is the most common clinical presentation of paraneoplastic encephalomyelitis. Clinical signs include asymmetric paresthesia of the face, trunk and proximal extremities followed by lancinating pain, vibrioceptive and proprioceptive impairment, and muted reflexes. Clinical course usually follows a progressive neurologic deterioration which stabilizes at a level of severe, permanent disability." @default.