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- Bbf97e4b02e219a68e8c4136e70b48ea8 NCIT_P378 "NCI" @default.
- Bbf97e4b02e219a68e8c4136e70b48ea8 type Axiom @default.
- Bbf97e4b02e219a68e8c4136e70b48ea8 annotatedProperty IAO_0000115 @default.
- Bbf97e4b02e219a68e8c4136e70b48ea8 annotatedSource NCIT_C61894 @default.
- Bbf97e4b02e219a68e8c4136e70b48ea8 annotatedTarget "A mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death." @default.