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- Bc009531bed7c40627bd6ce9c26549244 NCIT_P378 "NCI" @default.
- Bc009531bed7c40627bd6ce9c26549244 type Axiom @default.
- Bc009531bed7c40627bd6ce9c26549244 annotatedProperty IAO_0000115 @default.
- Bc009531bed7c40627bd6ce9c26549244 annotatedSource NCIT_C2415 @default.
- Bc009531bed7c40627bd6ce9c26549244 annotatedTarget "The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy." @default.