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- Bc00ea66302101e3c6d7f60388ee8d571 NCIT_P378 "NCI" @default.
- Bc00ea66302101e3c6d7f60388ee8d571 type Axiom @default.
- Bc00ea66302101e3c6d7f60388ee8d571 annotatedProperty IAO_0000115 @default.
- Bc00ea66302101e3c6d7f60388ee8d571 annotatedSource NCIT_C76404 @default.
- Bc00ea66302101e3c6d7f60388ee8d571 annotatedTarget "An orally bioavailable cyclopentyltriazolopyrimidine, with antiplatelet activity. Upon oral administration, ticagrelor and its major metabolite targets and reversibly binds to the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R) at a site distinct from that of the endogenous agonist ADP. This blocks the platelet signaling pathway, thereby inhibiting the activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation." @default.