Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bc03ad4d73dfdb1517cd5eee4f9ae48e5> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bc03ad4d73dfdb1517cd5eee4f9ae48e5 NCIT_P378 "NCI" @default.
- Bc03ad4d73dfdb1517cd5eee4f9ae48e5 type Axiom @default.
- Bc03ad4d73dfdb1517cd5eee4f9ae48e5 annotatedProperty IAO_0000115 @default.
- Bc03ad4d73dfdb1517cd5eee4f9ae48e5 annotatedSource NCIT_C28823 @default.
- Bc03ad4d73dfdb1517cd5eee4f9ae48e5 annotatedTarget "A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria." @default.