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- Bc06944a431c2b319209e0e20bd88c300 NCIT_P378 "NCI" @default.
- Bc06944a431c2b319209e0e20bd88c300 type Axiom @default.
- Bc06944a431c2b319209e0e20bd88c300 annotatedProperty IAO_0000115 @default.
- Bc06944a431c2b319209e0e20bd88c300 annotatedSource NCIT_C65268 @default.
- Bc06944a431c2b319209e0e20bd88c300 annotatedTarget "The mesylate salt of bitolterol, a diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function." @default.