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- Bc08aea2ef1796f08aa63880c2926a19b NCIT_P378 "NCI" @default.
- Bc08aea2ef1796f08aa63880c2926a19b type Axiom @default.
- Bc08aea2ef1796f08aa63880c2926a19b annotatedProperty IAO_0000115 @default.
- Bc08aea2ef1796f08aa63880c2926a19b annotatedSource NCIT_C80059 @default.
- Bc08aea2ef1796f08aa63880c2926a19b annotatedTarget "An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks." @default.