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- Bc08dfa07e753d3e741a2069677b749bf NCIT_P378 "NCI" @default.
- Bc08dfa07e753d3e741a2069677b749bf type Axiom @default.
- Bc08dfa07e753d3e741a2069677b749bf annotatedProperty IAO_0000115 @default.
- Bc08dfa07e753d3e741a2069677b749bf annotatedSource NCIT_C29263 @default.
- Bc08dfa07e753d3e741a2069677b749bf annotatedTarget "The lactate salt form of milrinone, a cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle." @default.