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- Bc2d804ca10fa1bad1938bf804ce4045c NCIT_P378 "BIOCARTA" @default.
- Bc2d804ca10fa1bad1938bf804ce4045c type Axiom @default.
- Bc2d804ca10fa1bad1938bf804ce4045c annotatedProperty NCIT_P325 @default.
- Bc2d804ca10fa1bad1938bf804ce4045c annotatedSource NCIT_C39148 @default.
- Bc2d804ca10fa1bad1938bf804ce4045c annotatedTarget "Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events to once per replication origin per S phase. Its control has been uncovered by the discovery of the cyclin dependent kinases (CDKs) as master regulators of the cell cycle and the initiator proteins of DNA replication, such as the Origin Recognition Complex (ORC), Cdc6/18, Cdt1 and the mini-chromosome maintenance complex (Mcm). The proteins and the sequence of events involved in this process are conserved throughout the eukaryotic kingdom. First, the ORC comprised of six proteins binds to replication origins in the chromosomal DNA. At the end of mitosis, ORC, Cdc6/18 and Cdt1 assist the binding of Mcm proteins 2-7 to chromatin, and chromatin becomes licensed for replication. The activated Mcm complex functions as a replicating helicase and moves along with the replication fork to bring the origins to the unlicensed state. The cycling of CDK activity in the cell cycle regulates the two states of replication origins, the licensed state in G1-phase and the unlicensed state for the rest of the cell cycle. The restriction on licensing is relieved when CDK falls off at the completion of mitosis to allow a new round of replication. (This definition may be outdated - see the DesignNote.)" @default.