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- Bc3d3d062fd94c186bf829c8ba97567b7 NCIT_P378 "NCI" @default.
- Bc3d3d062fd94c186bf829c8ba97567b7 type Axiom @default.
- Bc3d3d062fd94c186bf829c8ba97567b7 annotatedProperty IAO_0000115 @default.
- Bc3d3d062fd94c186bf829c8ba97567b7 annotatedSource NCIT_C47644 @default.
- Bc3d3d062fd94c186bf829c8ba97567b7 annotatedTarget "The nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth." @default.