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- Bc3f3c65c94ed7a71d5e7fb81d2bf0ca4 NCIT_P378 "NCI" @default.
- Bc3f3c65c94ed7a71d5e7fb81d2bf0ca4 type Axiom @default.
- Bc3f3c65c94ed7a71d5e7fb81d2bf0ca4 annotatedProperty IAO_0000115 @default.
- Bc3f3c65c94ed7a71d5e7fb81d2bf0ca4 annotatedSource NCIT_C47424 @default.
- Bc3f3c65c94ed7a71d5e7fb81d2bf0ca4 annotatedTarget "The hydrochloride salt form of buprenorphine, a synthetic phenanthrene with narcotic analgesic activity. Buprenorphine hydrochloride is a partial agonist at the mu-opioid receptor and an antagonist at the kapa-opioid receptor in the central nervous system. However, under the conditions of recommended use it behaves as a classic mu-opioid agonist, mimicking the actions of endogenous peptides at CNS opioid receptors. The agonist action results in a raised pain threshold and increased tolerance to pain. However, it also causes sedation, physical dependence, and respiratory depressant effects and decreases heart rate and blood pressure." @default.