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- Bc4680dbc0338985c4bc0e7d32b646224 NCIT_P378 "NCI" @default.
- Bc4680dbc0338985c4bc0e7d32b646224 type Axiom @default.
- Bc4680dbc0338985c4bc0e7d32b646224 annotatedProperty IAO_0000115 @default.
- Bc4680dbc0338985c4bc0e7d32b646224 annotatedSource NCIT_C102850 @default.
- Bc4680dbc0338985c4bc0e7d32b646224 annotatedTarget "An amonafide (naphthalimide) derivative and pan-antagonist of chemokine ligand (CXCL) expression, with potential anti-angiogenic activity. Although UNBS5162 is a derivative of amonafide, this agent appears to have a different profile to that of amonafide and its exact mechanism of action remains to be fully elucidated. This agent seems to decrease the expression of various proangiogenic CXCL chemokines in vitro and may have synergistic effects with radiotherapy or chemotherapy. CXCLs are small cytokines in the CXC chemokine family that are overexpressed in certain cancers; CXCL-mediated signaling plays a key role in angiogenesis and tumor progression." @default.