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- Bc471cb4930279fc3cc9ad7a2e91b05a9 NCIT_P378 "NCI" @default.
- Bc471cb4930279fc3cc9ad7a2e91b05a9 type Axiom @default.
- Bc471cb4930279fc3cc9ad7a2e91b05a9 annotatedProperty IAO_0000115 @default.
- Bc471cb4930279fc3cc9ad7a2e91b05a9 annotatedSource NCIT_C118625 @default.
- Bc471cb4930279fc3cc9ad7a2e91b05a9 annotatedTarget "A soluble fusion protein containing the extracellular domain of the activin receptor type 2B (ACVR2B or ActRIIB) fused to a human Fc domain, with potential antineoplastic activity. Upon intravenous administration, STM 434 selectively binds to the growth factor activin A, thereby preventing its binding to and the activation of endogenous ActRIIB. This prevents activin A/ActRIIB-mediated signaling and inhibits the proliferation of activin A-overexpressing tumor cells. Activin A, a member of the transforming growth factor beta (TGF-beta) superfamily, is overexpressed in a variety of cancers and plays a key role in promoting cancer cell proliferation, migration, and survival." @default.