Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bc49327ea89ffce692a401a61e2621416> ?p ?o ?g. }
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- Bc49327ea89ffce692a401a61e2621416 NCIT_P378 "NCI" @default.
- Bc49327ea89ffce692a401a61e2621416 type Axiom @default.
- Bc49327ea89ffce692a401a61e2621416 annotatedProperty IAO_0000115 @default.
- Bc49327ea89ffce692a401a61e2621416 annotatedSource NCIT_C66322 @default.
- Bc49327ea89ffce692a401a61e2621416 annotatedTarget "A monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect." @default.