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- Bc4c05e9894d5fafb941714a996cbedc7 NCIT_P378 "NCI" @default.
- Bc4c05e9894d5fafb941714a996cbedc7 type Axiom @default.
- Bc4c05e9894d5fafb941714a996cbedc7 annotatedProperty IAO_0000115 @default.
- Bc4c05e9894d5fafb941714a996cbedc7 annotatedSource NCIT_C25965 @default.
- Bc4c05e9894d5fafb941714a996cbedc7 annotatedTarget "Expressed in a variety of tissues, Toll-Like Receptor Family Genes encode type I transmembrane Toll-Like Receptor proteins, containing a TIR domain and multiple LRR repeats, which respond to various microbial components and mediate pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLRs typically act via MyD88 (TIR interaction) and TRAF6, activating NF-Kappa-B, cytokine production and secretion, and inflammatory response. (NCI)" @default.