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- Bc4cad1bab2ef17df60c47ba63e027b74 NCIT_P378 "NCI" @default.
- Bc4cad1bab2ef17df60c47ba63e027b74 type Axiom @default.
- Bc4cad1bab2ef17df60c47ba63e027b74 annotatedProperty IAO_0000115 @default.
- Bc4cad1bab2ef17df60c47ba63e027b74 annotatedSource NCIT_C984 @default.
- Bc4cad1bab2ef17df60c47ba63e027b74 annotatedTarget "A derivative of D-glucaro-1, 4-lactone with chemopreventive and anti-tumor activities. One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by glucuronidation. When beta-glucuronidase deconjugates these glucuronides, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Thereby, aceglatone may suppress the developments of hormone-dependent cancers mediated through beta-glucuronidase inhibition." @default.