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- Bc54b9d0e2a0ed2bcb16a69ff3a915cad NCIT_P378 "NCI" @default.
- Bc54b9d0e2a0ed2bcb16a69ff3a915cad type Axiom @default.
- Bc54b9d0e2a0ed2bcb16a69ff3a915cad annotatedProperty IAO_0000115 @default.
- Bc54b9d0e2a0ed2bcb16a69ff3a915cad annotatedSource NCIT_C77876 @default.
- Bc54b9d0e2a0ed2bcb16a69ff3a915cad annotatedTarget "An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Glesatinib binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs." @default.