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- Bc661858c93262a7c4923b7051b2a0c11 NCIT_P378 "NCI" @default.
- Bc661858c93262a7c4923b7051b2a0c11 type Axiom @default.
- Bc661858c93262a7c4923b7051b2a0c11 annotatedProperty IAO_0000115 @default.
- Bc661858c93262a7c4923b7051b2a0c11 annotatedSource NCIT_C156737 @default.
- Bc661858c93262a7c4923b7051b2a0c11 annotatedTarget "An orally available, small-molecule inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1; receptor-interacting protein 1; RIP1) with potential antineoplastic and immunomodulatory activities. Upon administration, GSK3145095 disrupts RIPK1-mediated signaling, which may reduce C-X-C motif chemokine ligand 1 (CXCL1)-driven recruitment and migration of immunosuppressive myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME). This allows effector cells, such as natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs), to kill and eliminate cancer cells. RIPK1, a serine-threonine kinase that normally plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition, is overexpressed in certain cancer types and may be associated with oncogenesis and promotion of the immunosuppressive nature of the TME." @default.