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- Bc718b11a19e2331cce54dc065c52ccaa NCIT_P378 "NCI" @default.
- Bc718b11a19e2331cce54dc065c52ccaa type Axiom @default.
- Bc718b11a19e2331cce54dc065c52ccaa annotatedProperty IAO_0000115 @default.
- Bc718b11a19e2331cce54dc065c52ccaa annotatedSource NCIT_C47704 @default.
- Bc718b11a19e2331cce54dc065c52ccaa annotatedTarget "A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission." @default.