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- Bc790c4661dd28c3afac1763025f7294a NCIT_P378 "NCI" @default.
- Bc790c4661dd28c3afac1763025f7294a type Axiom @default.
- Bc790c4661dd28c3afac1763025f7294a annotatedProperty IAO_0000115 @default.
- Bc790c4661dd28c3afac1763025f7294a annotatedSource NCIT_C48031 @default.
- Bc790c4661dd28c3afac1763025f7294a annotatedTarget "The hydrochloride salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone hydrochloride functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone hydrochloride also inhibits synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone hydrochloride exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors." @default.