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- Bc7b411a695ba6f3c8da32f2c9baf9820 NCIT_P378 "NCI" @default.
- Bc7b411a695ba6f3c8da32f2c9baf9820 type Axiom @default.
- Bc7b411a695ba6f3c8da32f2c9baf9820 annotatedProperty IAO_0000115 @default.
- Bc7b411a695ba6f3c8da32f2c9baf9820 annotatedSource NCIT_C85523 @default.
- Bc7b411a695ba6f3c8da32f2c9baf9820 annotatedTarget "A thiosemicarbazone prodrug with antitubercular activity. Although the exact mechanism by which thioacetazone exerts its effect has yet to be fully elucidated, this agent, upon activation by bacterial monooxygenase EtaA, appears to target and inhibit cyclopropane mycolic acid synthases (CMASs), a family of S-adenosyl-methionine-dependent methyl transferases responsible for cyclopropanation of mycolic acid. By inhibiting mycolic acid synthesis, the bacterial cell wall becomes more permeable and less resistant to injury which eventually leads to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence." @default.