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- Bc7b411c93f64bbe6f9a530083d0ae229 NCIT_P378 "KEGG" @default.
- Bc7b411c93f64bbe6f9a530083d0ae229 type Axiom @default.
- Bc7b411c93f64bbe6f9a530083d0ae229 annotatedProperty NCIT_P325 @default.
- Bc7b411c93f64bbe6f9a530083d0ae229 annotatedSource NCIT_C91481 @default.
- Bc7b411c93f64bbe6f9a530083d0ae229 annotatedTarget "Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells." @default.