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- Bc7c2c42e4add83abd787d6a2329e31fe NCIT_P378 "NCI" @default.
- Bc7c2c42e4add83abd787d6a2329e31fe type Axiom @default.
- Bc7c2c42e4add83abd787d6a2329e31fe annotatedProperty IAO_0000115 @default.
- Bc7c2c42e4add83abd787d6a2329e31fe annotatedSource NCIT_C82413 @default.
- Bc7c2c42e4add83abd787d6a2329e31fe annotatedTarget "An orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis." @default.