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- Bc9d702bb6af73d58f1a9a544437efd24 NCIT_P378 "NCI" @default.
- Bc9d702bb6af73d58f1a9a544437efd24 type Axiom @default.
- Bc9d702bb6af73d58f1a9a544437efd24 annotatedProperty IAO_0000115 @default.
- Bc9d702bb6af73d58f1a9a544437efd24 annotatedSource NCIT_C78848 @default.
- Bc9d702bb6af73d58f1a9a544437efd24 annotatedTarget "A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Sonolisib inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.