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- Bca5fee5f138e2cadab2a5b5c4986188b NCIT_P378 "NCI" @default.
- Bca5fee5f138e2cadab2a5b5c4986188b type Axiom @default.
- Bca5fee5f138e2cadab2a5b5c4986188b annotatedProperty IAO_0000115 @default.
- Bca5fee5f138e2cadab2a5b5c4986188b annotatedSource NCIT_C97332 @default.
- Bca5fee5f138e2cadab2a5b5c4986188b annotatedTarget "A third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as well as reduced toxicity. In addition, this agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump often overexpressed in cancer cells." @default.