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- Bcb2d9b39640283832bcc0bb00b811d03 NCIT_P378 "NCI" @default.
- Bcb2d9b39640283832bcc0bb00b811d03 type Axiom @default.
- Bcb2d9b39640283832bcc0bb00b811d03 annotatedProperty IAO_0000115 @default.
- Bcb2d9b39640283832bcc0bb00b811d03 annotatedSource NCIT_C47390 @default.
- Bcb2d9b39640283832bcc0bb00b811d03 annotatedTarget "The hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen." @default.