Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bcb3f047708c03e8835b1d4a43579864b> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bcb3f047708c03e8835b1d4a43579864b NCIT_P378 "NCI" @default.
- Bcb3f047708c03e8835b1d4a43579864b type Axiom @default.
- Bcb3f047708c03e8835b1d4a43579864b annotatedProperty IAO_0000115 @default.
- Bcb3f047708c03e8835b1d4a43579864b annotatedSource NCIT_C111041 @default.
- Bcb3f047708c03e8835b1d4a43579864b annotatedTarget "Allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63, coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells." @default.