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- Bcb45ebd5643bead38b5f8166c1dcc014 NCIT_P378 "NCI" @default.
- Bcb45ebd5643bead38b5f8166c1dcc014 type Axiom @default.
- Bcb45ebd5643bead38b5f8166c1dcc014 annotatedProperty IAO_0000115 @default.
- Bcb45ebd5643bead38b5f8166c1dcc014 annotatedSource NCIT_C73834 @default.
- Bcb45ebd5643bead38b5f8166c1dcc014 annotatedTarget "The hydrochloride salt form of a semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis." @default.