Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bcb556e61d43ced6c0e10787e61d9a0b0> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bcb556e61d43ced6c0e10787e61d9a0b0 NCIT_P378 "NCI" @default.
- Bcb556e61d43ced6c0e10787e61d9a0b0 type Axiom @default.
- Bcb556e61d43ced6c0e10787e61d9a0b0 annotatedProperty IAO_0000115 @default.
- Bcb556e61d43ced6c0e10787e61d9a0b0 annotatedSource NCIT_C116890 @default.
- Bcb556e61d43ced6c0e10787e61d9a0b0 annotatedTarget "A nanoparticle albumin-bound formulation of a thiocolchicine dimer, an inhibitor of both microtubule and topoisomerase I (TOP1), with antineoplastic and vascular disrupting activities. Upon administration of nanoparticle albumin-bound thiocolchicine dimer nab-5404, this agent binds to tubulin and inhibits its polymerization, which blocks mitotic spindle formation and leads to cell cycle arrest and tumor endothelial cell apoptosis. This disrupts the tumor vasculature and leads to tumor necrosis. In addition, nab-5404 binds to topoisomerase I (TOPI) and inhibits its activity. This results in the inhibition of the repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. The nanoparticle albumin-based formulation permits the albumin-mediated endocytosis of the thiocolchicine dimer by tumor cells and endothelial cells." @default.