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- Bcbba576197fae2cfa68ae069c397caab NCIT_P378 "NCI" @default.
- Bcbba576197fae2cfa68ae069c397caab type Axiom @default.
- Bcbba576197fae2cfa68ae069c397caab annotatedProperty IAO_0000115 @default.
- Bcbba576197fae2cfa68ae069c397caab annotatedSource NCIT_C1303 @default.
- Bcbba576197fae2cfa68ae069c397caab annotatedTarget "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04)" @default.