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- Bcbd97b5fb18c6a29f9fce45a8ec58413 NCIT_P378 "NCI" @default.
- Bcbd97b5fb18c6a29f9fce45a8ec58413 type Axiom @default.
- Bcbd97b5fb18c6a29f9fce45a8ec58413 annotatedProperty IAO_0000115 @default.
- Bcbd97b5fb18c6a29f9fce45a8ec58413 annotatedSource NCIT_C85469 @default.
- Bcbd97b5fb18c6a29f9fce45a8ec58413 annotatedTarget "A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival." @default.