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- Bcc27ddc8fc7da23a74cd5f101756d16a NCIT_P378 "NCI" @default.
- Bcc27ddc8fc7da23a74cd5f101756d16a type Axiom @default.
- Bcc27ddc8fc7da23a74cd5f101756d16a annotatedProperty IAO_0000115 @default.
- Bcc27ddc8fc7da23a74cd5f101756d16a annotatedSource NCIT_C77591 @default.
- Bcc27ddc8fc7da23a74cd5f101756d16a annotatedTarget "A recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF), with potential immunostimulating activity. Upon administration as inhalation solution via nebulizer, molgramostim binds to specific cell surface receptors and promotes or restores GM-CSF signaling, thereby modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. This agent also activates neutrophils, monocytes, macrophages, and dendritic cells and promotes antigen presentation, upregulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin (IL)-2-mediated, lymphokine-activated killer cell function. In addition, the restoration of GM-CSF signaling promotes surfactant clearing by pulmonary alveolar macrophages." @default.