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- Bcc40893d6ab8c44ea298b57897bb4e10 NCIT_P378 "NCI" @default.
- Bcc40893d6ab8c44ea298b57897bb4e10 type Axiom @default.
- Bcc40893d6ab8c44ea298b57897bb4e10 annotatedProperty IAO_0000115 @default.
- Bcc40893d6ab8c44ea298b57897bb4e10 annotatedSource NCIT_C78843 @default.
- Bcc40893d6ab8c44ea298b57897bb4e10 annotatedTarget "An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Hsp90, a 90 kDa molecular chaperone, may be highly expressed in tumor cells, playing a key role in the conformational maturation, stability and function of other substrate or "client" proteins within the cell; many of these client proteins are involved in signal transduction, cell cycle regulation and apoptosis, and may include kinases, transcription factors and hormone receptors." @default.