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- Bcc4d059ff2b38d47d531c188d0dc4550 NCIT_P378 "NCI" @default.
- Bcc4d059ff2b38d47d531c188d0dc4550 type Axiom @default.
- Bcc4d059ff2b38d47d531c188d0dc4550 annotatedProperty IAO_0000115 @default.
- Bcc4d059ff2b38d47d531c188d0dc4550 annotatedSource NCIT_C26423 @default.
- Bcc4d059ff2b38d47d531c188d0dc4550 annotatedTarget "This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)" @default.