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- Bcce49a997375e466d71181b1056e8fbb NCIT_P378 "NCI" @default.
- Bcce49a997375e466d71181b1056e8fbb type Axiom @default.
- Bcce49a997375e466d71181b1056e8fbb annotatedProperty IAO_0000115 @default.
- Bcce49a997375e466d71181b1056e8fbb annotatedSource NCIT_C96735 @default.
- Bcce49a997375e466d71181b1056e8fbb annotatedTarget "A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma tyrosinase A2 epitope YMDGTMSQV, with potential antineoplastic activity. Via the toxin moiety, the recombinant B. pertussis adenylate cyclase toxin-tyrosinase A2 epitope specifically binds to the alphaMbeta2 integrin (CD11b/CD18) located on CD11b-positive antigen-presenting cells (APC). Upon processing and presentation of the melanoma-specific epitope by MHC class I molecules to the surface of these APCs, a specific cytotoxic T-cell (CTL) response against tumor cells expressing tyrosinase may be initiated, resulting in decreased tumor growth and cell lysis." @default.