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- Bcd15cf40f79bdbfb1dfdf13dd5e4916a NCIT_P378 "NCI" @default.
- Bcd15cf40f79bdbfb1dfdf13dd5e4916a type Axiom @default.
- Bcd15cf40f79bdbfb1dfdf13dd5e4916a annotatedProperty IAO_0000115 @default.
- Bcd15cf40f79bdbfb1dfdf13dd5e4916a annotatedSource NCIT_C1258 @default.
- Bcd15cf40f79bdbfb1dfdf13dd5e4916a annotatedTarget "A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI04)" @default.