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- Bcd8a2f5476a982f22caedd52913f185e NCIT_P378 "NCI" @default.
- Bcd8a2f5476a982f22caedd52913f185e type Axiom @default.
- Bcd8a2f5476a982f22caedd52913f185e annotatedProperty IAO_0000115 @default.
- Bcd8a2f5476a982f22caedd52913f185e annotatedSource NCIT_C71156 @default.
- Bcd8a2f5476a982f22caedd52913f185e annotatedTarget "The magnesium salt of valproic acid (2-propylpentanoic acid) with antiepileptic and potential antineoplastic activities. Magnesium valproate dissociates in the gastrointestinal tract and is absorbed into the circulation as magnesium ions and valproic acid ions; valproic acid may inhibit histone deacetylases, inducing tumor cell differentiation, apoptosis, and growth arrest. In addition, valproic acid exerts an antiepileptic effect, likely by inhibiting enzymes that catabolize the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) catabolism and so increasing concentrations of GABA in the central nervous system (CNS). The presence of the magnesium in this agent may contribute to its anticonvulsant activity and sedative properties." @default.