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- Bcddc8ca8952f7482e361d314821bb9b5 NCIT_P378 "NCI" @default.
- Bcddc8ca8952f7482e361d314821bb9b5 type Axiom @default.
- Bcddc8ca8952f7482e361d314821bb9b5 annotatedProperty IAO_0000115 @default.
- Bcddc8ca8952f7482e361d314821bb9b5 annotatedSource NCIT_C179628 @default.
- Bcddc8ca8952f7482e361d314821bb9b5 annotatedTarget "An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic and anti-fibrotic activities. Upon oral administration, BET inhibitor JAB-8263 targets and binds to bromodomain-containing proteins 2, 3, and 4 (BRD2, BRD3, and BRD4) as well as bromodomain testis-specific protein (BRDT), thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and suppresses the expression of certain oncogenes and profibrotic genes, including Myc and other transcriptional regulators. Preventing the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth and fibrosis. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth." @default.