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- Bcde4acdc4f674621044f88f1d2970c75 NCIT_P378 "NCI" @default.
- Bcde4acdc4f674621044f88f1d2970c75 type Axiom @default.
- Bcde4acdc4f674621044f88f1d2970c75 annotatedProperty IAO_0000115 @default.
- Bcde4acdc4f674621044f88f1d2970c75 annotatedSource NCIT_C152302 @default.
- Bcde4acdc4f674621044f88f1d2970c75 annotatedTarget "A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin 6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-inflammatory cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation." @default.